Diagnosis and treatment of AUR-1 and/or AUR-2 related disorders
AssigneeSugen, Inc.
InventorsGregory Plowman, Kevin Mossie
Life of this patent
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Abstract
The present invention relates to AUR-1 and/or AUR-2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR-1 and/or AUR-2 related diseases or conditions characterized by an abnormal interaction between a AUR-1 and/or AUR-2 polypeptide and a AUR-1 and/or AUR-2 binding partner.
Claims20
An isolated, enriched or purified nucleic acid molecule that encodes at least 100 contiguous amino acids of the amino acid sequence depicted in SEQ ID NO:4.
An isolated, enriched or purified nucleic acid molecule comprising the nucleic acid sequence depicted in SEQ ID NO:2.
An isolated, enriched or purified nucleic acid molecule comprising (a) a nucleotide sequence that encodes a polypeptide having the amino acid sequence depicted in SEQ ID NO:4, or (b) the complement of the nucleotide sequence of (a).
An isolated, enriched or purified nucleic acid molecule that encodes at least 100 contiguous amino acids of the amino acid sequence depicted in SEQ ID NO:3.
An isolated, enriched or purified nucleic acid molecule comprising the nucleic acid sequence depicted in SEQ ID NO:1.
An isolated, enriched or purified nucleic acid molecule comprising (a) a nucleotide sequence that encodes a polypeptide having the amino acid sequence depicted in SEQ ID NO:3, or (b) the complement of the nucleotide sequence of (a).
A nucleic acid probe for the detection of nucleic acid encoding an AUR-2 polypeptide in a sample, the complement of said probe able to encode at least 100 contiguous amino acids of the amino acid sequence depicted in SEQ ID NO:4.
A nucleic acid probe for the detection of nucleic acid encoding an AUR-1 polypeptide in a sample, the complement of said probe able to encode at least 100 contiguous amino acids of the amino acid sequence depicted in SEQ ID NO:3.
Dependencies are inferred from the claim text.