Short-shafted adenoviral fiber and its use
AssigneeGenVec, Inc.
InventorsThomas J. Wickham, Petrus W. Roelvink, Imre Kovesdi
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Abstract
The present invention provides a short-shafted adenoviral fiber, a recombinant adenovirus comprising a short-shafted fiber, a vector comprising a short-shafted adenoviral fiber gene, and a method of targeting attachment of a short-shafted recombinant adenovirus to a cell so as to effect entry of the short-shafted recombinant adenovirus into the cell.
Claims60
A recombinant adenovirus comprising (a) a short-shafted fiber and (b) a nonnative gene that is expressed in a cell to which the recombinant adenovirus attaches or by which the recombinant adenovirus is internalized.
A recombinant baculovirus comprising a short-shafted adenoviral fiber gene, wherein said gene encodes a short-shafted adenoviral fiber protein comprising a tail, a shaft, and a knob.
A short-shafted adenoviral fiber comprising a tail, a shaft, and a knob.
A viral transfer vector comprising a short-shafted adenoviral fiber gene, wherein said gene encodes a short-shafted adenoviral fiber protein comprising a tail, a shaft, and a knob.
A prokaryotic or eukaryotic expression vector comprising a short-shafted adenoviral fiber gene, wherein said gene encodes a short-shafted adenoviral fiber protein comprising a tail, a shaft, and a knob.
Dependencies are inferred from the claim text.