Human signal transduction serine/threonine kinase
AssigneeZeneca Limited
InventorsTyrrell Errick Norris, William Craig Moore, David Shay Silberstein
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Abstract
A novel human signal-transduction kinase polypeptide is described which is expressed at a particularly high level in tissues of the human immune system. A full length cDNA which encodes the novel signal transduction serine/threonine kinase polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the native biological molecule. Methods are provided to identify compounds that modulate the biological activity of the human Ste20-like serine/threonine signal transduction kinase.
Claims9
A purified polynucleotide comprising a nucleic acid sequence encoding a polypeptide comprising SEQ ID NO:3 or a variant of SEQ ID NO:3 that differs from SEQ ID NO:3 by at least one conservative amino acid substitution.
A purified polynucleotide comprising a nucleic acid sequence which encodes a polypeptide comprising a polypeptide selected from the group consisting of:
- SEQ ID NO:11, and SEQ ID NO:3 wherein position 53 is arginine.
A method for producing a polypeptide, said method comprising a) culturing the host cell according to claim 5 under conditions for the expression of a polypeptide, and b) recovering said polypeptide from the host cell culture.
An antisense molecule comprising the complement of a polynucleotide comprising the sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:12.
A diagnostic composition for the identification of a polynucleotide sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:12, comprising polymerase chain reaction primers complementary to said sequence.
Dependencies are inferred from the claim text.