Mycobacterium proteins and applications
AssigneeInstitut Pasteur
InventorsGilles Marchal, Felix Romain, Pascale Pescher
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Abstract
Mycobacterium proteins, in particular those of M. bovis, having molecular weights between approximately 44.5 and 47.5 kD. These proteins can have molecular weights of approximately 45 kD or 47 kD and isoelectric pH of approximately 3.7 (45 and 47 kD proteins) and 3.9 (47 kD proteins). These proteins or hybrid proteins containing a part of their sequences can be used as vaccines or as drugs, or for the detection and monitoring of tuberculosis in particular in man and in cattle.
Claims12
An isolated protein from Mycobacterium having a molecular weight between approximately 45 and 47 kD, wherein said protein is recognized by antibodies obtained by immunization with live M. bovis bacilli, by antibodies from tubercular patients and by an antibody secreted by a hybridoma deposited at the CNCM having accession no. I-1081, wherein said protein is not recognized by antibodies obtained by immunization with heat-killed M. bovis bacilli or by antibodies from healthy patients or patients affected by a disease other than tuberculosis.
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