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US 5,962,044 AGranted
Citrus extract
AssigneeBioavailability Systems, LLC
InventorJames W. Harris
Life of this patent
Estimating the term…
Abstract
A safe, effective first-pass inhibiting citrus-derived substance.
Claims8
A method for inhibiting the first pass effect of a material taken orally by a patient which is subject to the first pass effect, comprising the step of co-administering to said patient a first-pass effective citrus-derived substance produced by a method comprising:
- reducing the concentration of volatile materials contained in a citrus-derived substance to produce a citrus-derived product,
- extracting said citrus-derived product with a 60/40 to 40/60 vol/vol mixture of at least one C.sub.2-4 alcohol and water to reduce the concentration of phototoxic furocoumarins therein and produce a first-pass effective citrus-derived substance.
A method for inhibiting the first pass effect of a material taken orally by a patient which is subject to the first pass effect, comprising the step of co-administering to said patient a first-pass effective citrus-derived substance produced by a method comprising:
- reducing the concentration of volatile materials contained in a citrus-derived substance to produce a citrus-derived product,
- extracting said citrus-derived product with a mixture of at least one C.sub.2-4 alcohol and water to reduce the concentration of phototoxic furocoumarins therein and produce a first-pass effective citrus-derived substance, wherein said mixture contains 45-60% alcohol on a volume/volume basis.
Dependencies are inferred from the claim text.