Loading patent…
AssigneeOrion-yhtyma Oy
InventorsMartti Lauri Antero Marvola, Esko Veikko Marttila, Reija Tuulikki Yrjola, Esa Petteri Lahdenpaa
Estimating the term…
The invention relates to a peroral composition providing controlled release of a drug, the composition comprising a) a core comprising the drug and a drug release controlling agent and b) an enteric coating comprising the drug release controlling agent, wherein the drug release controlling agent consists substantially of a pH-sensitive enteric polymer. Preferably the pH-sensitive enteric polymer has a pH dissolving point of at least 6.5. The composition is preferably in the form of granules. Preferably, the composition is in the form of enteric matrix granules coated with an enteric coating. The composition releases the drug gradually in the lower gastrointestinal tract. The composition is especially suitable for the administration of 3-(3-cyanophenyl)methylene-2,4-pentanedione into the colon.
A peroral controlled release composition, wherein said composition releases a drug substantially in a colon, said composition comprising a) a core comprising said drug and a drug release controlling agent and b) an enteric coating comprising said drug release controlling agent, wherein said drug release controlling agent consists substantially of a pH-sensitive enteric polymer, wherein said pH-sensitive enteric polymer has a pH dissolving point of at least 6.5.
A method for preparing a peroral controlled release composition, wherein said composition releases a drug substantially in a colon, wherein said method comprises granulating said drug with a water-free solution of a pH-sensitive enteric polymer, wherein said pH-sensitive enteric polymer has a pH dissolving point of at least 6.5, screening a desired fraction of the resulting granules, and coating said granules with a coating comprising a pH-sensitive enteric polymer, wherein said pH-sensitive enteric polymer has a pH dissolving point of at least 6.5.
A method for preparing a peroral controlled release composition, wherein said composition releases a drug substantially in a colon, wherein said method comprises granulating said drug with a water-free solution of a pH-sensitive enteric polymer, wherein said pH-sensitive enteric polymer has a pH dissolving point of at least 6.5, screening the desired fraction of the resulting granules, pressing said granules into a tablet, and coating said tablet with a coating comprising a pH-sensitive enteric polymer, wherein said pH-sensitive enteric polymer has a pH dissolving point of at least 6.5.
Dependencies are inferred from the claim text.