Pharmaceutical formulation with effervescent couple
AssigneeSmithKline Beecham Corporation
InventorsIan James Bolt, David Roy Merrifield, Paul Laurence Carter
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Abstract
A chewable tablet comprises a medicament dispersed in a chewable base, such as mannitol, together with an effervescent couple, such as citric acid-sodium bicarbonate. The combination of effervescence and chewability with optional flavorings improves the taste characteristics of the medicament in oral administration. A disintegrant such as microcrystalline cellulose may be added to give the patient the option of dispersing the tablet in water.
Claims12
A tablet comprising a chewable base, nabumetone and an effervescent component comprised of an acid component and an alkaline component, wherein the nabumetone comprises at least 50% by weight of said tablet.
A chewable tablet comprising a chewable base, wherein said chewable base contains at least one member selected from the group consisting of mannitol, sorbitol, dextrose, fructose, and lactose, nabumetone, in an amount of at least 50% by weight, and an effervescent couple in which said effervescent couple comprises an acidic component comprising 0.5% to 20% by weight of said tablet wherein said acidic component is selected from the group consisting of citric acid tartaric acid, adipic acid, fumaric acid and malic acid, and acid salts thereof, and a base component comprising 0.5% to 30% by weight of said tablet, wherein said basic component is selected from the group consisting of sodium, potassium and calcium (bi) carbonates and sodium glycine carbonate, the effervescent couple comprising 1.0 to 30% of the weight of said tablet.
A tablet comprising a chewable base, nabumetone and an effervescent component comprised of an acid component and an alkaline component, wherein the nabumetone comprises at least 50% by weight of said tablet, and wherein the tablet further comprises as a disintegrating agent a member selected from the group consisting of sodium starch glycolate, microcrystalline cellulose, and PVP, or mixtures thereof.
Dependencies are inferred from the claim text.