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US 5,961,953 AGranted
Magnetic resonance blood pool agents
AssigneeMallinckrodt Inc.
InventorSteven R. Woulfe
Life of this patent
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Abstract
The present invention provides compositions comprising contrast agents capable of binding non-covalently to blood proteins. The compositions of the invention provide increased residence time of contrast agents in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention to a patient and obtaining an image.
Claims6
A composition comprising the formula (I):
- A--L--B (I)
- wherein A is selected from the group or derivatives of the group consisting of bicyclo2.2.2!octane, adamantane, and dicyclohexylacetyl:
- B is a chelate;
- L is a linker between A and B corresponding to a group of formula (II):
- ##STR5## in which n is an integer from about zero to about 6;
- R.sub.1, R.sub.2 and R.sub.3 may be the same or different and are hydrogen or --(CH.sub.2).sub.m --X;
- m is an integer from about zero to about 6;
- X is hydrogen, --NH.sub.2, --CO.sub.2 H, --SO.sub.3 H or --PO.sub.3 H.sub.2 ;
- B is a chelating agent of metal ions having atomic numbers selected from the set of numbers 22 through 29, 42 through 44 and 58 through 70.
6 more elements
Dependencies are inferred from the claim text.