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US 5,961,952 AGranted
.sup.99m Tc-tertiary-butyl isonitrile as breast tumor imaging agents
AssigneeDuPont Pharmaceuticals Company
InventorsPaul David Crane, David Charles Onthank, Milind Rajopadhye
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Abstract
A novel method of diagnosing or radioimaging breast tumors using .sup.99m Tc- or .sup.186/188 Re-tertiary-butyl isonitrile complex and a kit for diagnosing or radioimaging breast tumors containing tertiary-butyl isonitrile and a solubilization aid are presented.
Claims40
A method of diagnosing breast tumors, comprising:
- (a) administering parenterally to a mammal an effective amount of a composition comprising an imaging agent selected from .sup.99m Tc-tertiary-butyl isonitrile complex and .sup.186/188 Re-tertiary-butyl isonitrile complex and a pharmaceutically acceptable carrier;
- and,
- (b) radioimaging the mammal to determine whether a breast tumor is present.
A method of radioimaging breast tumors, comprising:
- (a) administering parenterally to a mammal an effective amount of a composition comprising an imaging agent selected from .sup.99m Tc-tertiary-butyl isonitrile complex and .sup.186/188 Re-tertiary-butyl isonitrile complex and a pharmaceutically acceptable carrier;
- and,
- (b) radioimaging the mammal after allowing sufficient time for the composition to localize in a breast tumor present in the mammal.
Dependencies are inferred from the claim text.