Back to results
US 5,961,469 AGranted
Spectrophotometric assay for cyanide
OwnerMichael F. Roizen, Jon Mossinventors
Life of this patent
Estimating the term…
Abstract
A method of detecting and quantifying cyanide concentration in a patient, by monitoring photometric changes resulting from the transformation of methemoglobin to cyanomethemoglobin. The present invention provides for a means of cyanide poisoning assessment in patients using the affinity of methemoglobin for cyanide to assess the photometric changes resulting from methemoglobin converting to cyanomethemoglobin, as an indicator of cyanide concentration in a patient. Appropriate corrective action can then be promptly taken.
Claims31
A method of detecting cyanide in blood comprising:
- (a) acidifying a blood sample, wherein the blood sample comprises red blood cells and red blood cell membranes, to form an acidified sample;
- (b) trapping any hydrogen cyanide gas that forms in the acidified sample to form a trapped solution;
- (c) buffering the trapped solution to form a buffered trapped solution;
- (d) adding methemoglobin to the buffered trapped solution;
- (e) measuring any photometric change of the blood sample;
- and
- (f) taking corrective action to counter toxic levels of cyanide present.
4 more elements
A method of detecting cyanide in exhaled gas comprising:
- (a) blowing into a breath analyzer, wherein the breath analyzer comprises:
- a mouthpiece;
- a hollow chamber connected to the mouthpiece;
- and
- a matrix containing methemoglobin within the hollow chamber;
- and
- (b) measuring the matrix for photometric change indicative of the presence of cyanomethemoglobin.
4 more elements
Dependencies are inferred from the claim text.