Phenyl-substituted 5H-thiazolo›3,2-A!pyrimidine derivative glutamate receptor antagonists

Compounds of general formula ##STR10## wherein R.sup.1 is hydrogen, lower alkyl, phenyl or benzyl;

• R.sup.2 is lower alkyl, --O(CH.sub.2).sub.n N(R.sup.13 R.sup.14), -(CH.sub.2) . . . are each independently trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano --N(R.sup.13).sub.2, phenyl, phenyloxy, benzyl or benzyloxy, or R.sup.6 and R.sup.7 together are a benzene ring;
• R.sup.13, R.sup.14 and R.sup.15 are each independently hydrogen, lower alkyl or cycloalkyl;
• and n is 1-5, prepared by the process of reacting a compound of the formula ##STR11## with an .alpha.-bromo-acetaldehyde of the formula ##STR12## wherein R.sup.1 -R.sup.12 have the significance given above, and, if desired, converting a compound of formula I into a pharmaceutically acceptable salt.

Compounds of the general formula ##STR14## wherein R.sup.1 is hydrogen, lower alkyl, phenyl or benzyl;

• R.sup.2 is propoxy;
• R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 are each independently hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano, --N(R.sup.13).sub.2, phenyl, phenyloxy, benzyl or benzyloxy, or R.sup.6 and R.sup.7 together are a benzene ring;
• R.sup.13, R.sup.14, and R.sup.15 are each independently hydrogen, lower alkyl or cycloalkyl, as well as their pharmaceutically acceptable salts.