Use of modified tethers in screening compound libraries
AssigneeGlaxo Group Limited
InventorsWilliam J. Dower, Gregory L. Heinkel, Larry Mattheakis, Peter J. Schatz
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Abstract
The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
Claims44
A method of screening compounds for a desired property, the method comprising:
- providing a library of complexes, each complex comprising a compound under test, a tag recording at least one step in the synthesis of the compound, and a tether susceptible to modification by a reporter molecule produced in screening the test compounds, wherein at least one, but not all, of the complexes have a tether that has been modified by the reporter molecule, the modification indicating that the at least one complex bears a compound having the desired property;
- separating the at least one complex having a modified tether from the library by virtue of the modified tether;
- and
- decoding the tag of the at least one complex having the modified tether to identify at least one step in the synthesis of a compound having the desired property.
Dependencies are inferred from the claim text.