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AssigneeThe Trustees of Columbia University in the City of New York
InventorsPaul J. Maddon, Dan R. Littman, Leonard Chess, Richard Axel, Robin Weiss, J. Steven McDougal
Estimating the term…
A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4.sup.+ cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
A soluble human T4 protein having the amino acid sequence as follows:
A method of inhibiting the binding of human immunodeficiency virus to T4.sup.+ cells which comprises contacting the virus with an amount of a compound which inhibits binding of an extracellular target molecule to T4 protein effective to inhibit binding of the virus to T4.sup.+ cells wherein the inhibition occurs outside a subject and the compound is not an antibody.
A compound which inhibits binding of an extracellular target molecule to T4.sup.+ protein with the proviso that the compound is not an antibody.
Dependencies are inferred from the claim text.