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US 5,958,457 AGranted
Compositions for the delivery of antigens
AssigneeEmisphere Technologies, Inc.
InventorsNoemi B. Santiago, Susan Haas, Andrea Leone-Bay
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
Claims42
A composition comprising:
- (a) an antigen;
- (b) an adjuvant;
- (c) at least one carrier comprising a member selected from the groups consisting of:
- (i) an acylated amino acid or a salt thereof;
- (ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (iii) a sulfonated amino acid or a salt thereof;
- (iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (v) any combination thereof;
- wherein said adjuvant is selected from the group consisting of purified protein derivative (PPD), poly adenylic acid (poly A), polyuridylic acid (poly U), muramyl dipeptides, inulin, zymosan, levamisol, Corynebacterium parvum, polyphophazenes, bacterial toxins, bacterial toxin subunits, bacterial toxoids, or any combination thereof.
7 more elements
A composition comprising:
- (a) ovalbumin;
- (b) cholera toxin;
- and
- (c) at least one carrier comprising a member selected from the groups consisting of:
- (i) an acylated amino acid or a salt thereof;
- (ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (iii) a sulfonated amino acid or a salt thereof;
- (iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (v) any combination thereof.
7 more elements
A composition comprising:
- (a) Infectious Bursal Disease Virus;
- (b) cholera toxin;
- (c) cholera toxin .beta.-subunit;
- and
- (d) at least one carrier comprising a member selected from the groups consisting of:
- (i) an acylated amino acid or a salt thereof;
- (ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
- (iii) a sulfonated amino acid or a salt thereof;
- (iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
- or
- (v) any combination thereof.
8 more elements
A composition comprising:
- (a) an antigen;
- (b) an adjuvant;
- (c) at least one carrier comprising at least one (i) amino acid or polyamino acid modified by reaction with an amino acid reactive modifying agent selected from the group consisting of benzene sulfonyl chloride, benzoyl chloride, hippuryl chloride and amino acid carbodiimide, or (ii) a salt of (i);
- wherein said adjuvant is selected from the group consisting of polypeptide derivative (PPD), polyadenyic acid (poly A), polyuridylic acid (poly U), muramyl dipeptides, inulin, zymosan, levamisol, Corynebacterium parvum, polyphophazenes, bacterial toxins, bacterial toxin subunits, bacterial toxoids, or any combination thereof.
1 more element
A composition comprising:
- (a) ovalbumin;
- (b) cholera toxin;
- and
- (c) at least one carrier comprising at least one (i) amino acid or polyamino acid modified by reaction with an amino acid reactive modifying agent selected from the group consisting of benzene sulfonyl chloride, benzoyl chloride, hippuryl chloride and amino acid carbodiimide, or (ii) a salt of (i).
1 more element
A composition comprising:
- (a) Infectious Bursal Disease Virus;
- (b) cholera toxin;
- (c) cholera toxin .beta.-subunit;
- and
- (d) at least one carrier comprising at least one (i) amino acid or polyamino acid modified by reaction with an amino acid reactive modifying agent selected from the group consisting of benzene sulfonyl chloride, benzoyl chloride, hippuryl chloride and amino acid carbodiimide, or (ii) a salt of (i).
2 more elements
A method for preparing microspheres, said method comprising:
- (A) solubilizing, in a solvent, at least one carrier to provide a carrier solution;
- and
- (B) contacting said carrier solution with an antigen, an adjuvant, and a precipitator solution in which said carrier is insoluble;
- wherein said carrier comprises at least one carrier comprising at least one
- (i) amino acid or polyamino acid modified by reaction with an amino acid reactive modifying agent selected from the group consisting of benzene sulfonyl chloride, benzoyl chloride, hippuryl chloride and amino acid carbodiimide, or
- (ii) a salt of (I);
- wherein said adjuvant is selected from the group consisting of purified protien derivative (PPD), polyadenylic acid (poly A), polyuridylic acid (poly U), muramyl dipeptides, inulin, zymosan, levamisol, Corynebacterium parvum, polyphophazenes, bacterial toxins, bacterial toxin subunits, bacterial toxoids, or any combination thereof.
4 more elements
Dependencies are inferred from the claim text.