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AssigneeNoven Pharmaceuticals, Inc.
InventorsJesus Miranda, Steven Sablotsky
Estimating the term…
The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.
A dermal composition, comprising a blend of:
A pressure-sensitive adhesive composition for dermal administration of a drug comprising a blend of:
A process for transdermally administering to a mammal a therapeutically effective amount of a drug, comprising the steps of applying a composition for transdermal administration of the drug to the skin of said mammal, and maintaining said composition in contact with said skin until said effective amount of said preselected drug is transdermally administered, wherein said composition comprises a blend of
A dermal composition, comprising a blend of:
A composition for dermal administration of a drug, comprising a blend of:
Dependencies are inferred from the claim text.