Medical uses of in situ formed gels
AssigneeMDV Technologies, Inc.
InventorsTacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
Life of this patent
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Abstract
Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
Claims39
An aqueous drug delivery composition capable of gelling in situ to produce a hyperosmotic, hypoosmotic or isoosmotic gel having a buffered pH, said composition comprising at least one ionic polysaccharide and at least one film forming agent.
A composition capable of gelling in situ to produce a hyperosmotic, hypoosmotic or isoosmotic gel having a buffered pH, said composition comprising:
- A) an aqueous vehicle comprising at least one ionic polysaccharide;
- and
- B) an aqueous solution comprising a counter-ion capable of gelling said ionic polysaccharide,
- wherein combining A) and B) results in an aqueous gel vehicle.
A diagnostic agent vehicle composition capable of gelling in situ to produce a hyperosmotic, hypoosmotic or isoosmotic gel having a buffered pH, said composition comprising at least one ionic polysaccharide and at least one film forming agent.
A composition for the prevention of post-operative adhesions capable of gelling in situ to produce a hyperosmotic, hypoosmotic or isoosmotic gel having a buffered pH, said composition comprising at least one ionic polysaccharide and at least one film forming agent.
A composition for the treatment of topical wounds capable of gelling in situ to produce a hyperosmotic, hypoosmotic or isoosmotic gel having a buffered pH, said composition comprising at least one ionic polysaccharide and at least one film forming agent.
A method for forming a protective layer over a wound comprising:
- A) applying a composition comprising at least one ionic polysaccharide and at least one film forming agent to the wound;
- and
- B) applying to said composition at least one cross-linking agent capable of cross-linking an ionic polysaccharide;
- wherein application of said agent results in the formation of said protective layer.
Dependencies are inferred from the claim text.