Formulations and methods for reducing skin irritation
AssigneeCosmederm Technologies
InventorsGary S. Hahn, David O. Thueson
Life of this patent
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Abstract
Compositions and methods are provided for inhibiting skin irritation attributable to chemical irritants, including skin exfoliant irritants, and environmental conditions by the application of an anti-irritant amount of aqueous-soluble divalent calcium cation.
Claims93
A skin exfoliant composition for topical application to an animal subject comprising
- a topical vehicle;
- one or more skin exfoliant irritant ingredients selected from the group consisting of carboxylic acids, keto acids, .alpha.-hydroxy acids, .beta.-hydroxy acids, retinoids, peroxides, and organic alcohols, said one or more skin exfoliant ingredients contained in a total amount of at least about 12% by weight and capable of inducing skin irritation and effecting exfoliation of the skin of said subject;
- and
- an anti-irritant amount of aqueous-soluble divalent calcium cation.
A skin exfoliant composition for topical application to an animal subject comprising
- a topical vehicle;
- one or more skin exfolliant irritant ingredients selected from the group consisting of carboxylic acids, keto acids, .alpha.-hydroxy acids, .beta.-hydroxy acids, retinoids, peroxides, and organic alcohols contained in an amount capable of inducing skin irritation and effecting exfoliation of the skin of said subject;
- and
- an anti-irritant amount of aqueous-soluble divalent calcium cation salt having, as a counteranion to strontium in said salt, one or more aqueous-ionizable anion species selected from the group consisting of nitrate, bicarbonate, hydroxide, oxide peroxide, nitrite, sulfide, bisulfate, persulfate, glycerophosphate, hypophosphate, borate and titanate inorganic anions, and aqueous-ionizable carboxylic acid, alkoxylate, amino acid, peptide, saturated organic acid, saturated and unsaturated fatty acid, oxalate, acetate, gluconate, lactate, tartrate, maleate, benzoate, propionate, salicylate, formate, succinate, folinate, aspartate, phthalate, oleate, palmitate, stearate, lauryl sulfate, lanolate, myristate, behenate, caseinate, cyclamate, pantothenate, polyaminopolycarboxylates, saccharin, thioglycolate, laurate, methylparaben, propylparaben, ricinoleate and sorbate organic anions.
A method of reducing skin irritation caused by application of a skin exfoliant irritant ingredient selected from the group consisting of carboxylic acids, keto acids, .alpha.-hydroxy acids, .beta.-hydroxy acids, retinoids, peroxides, and organic alcohols, said method comprising the steps of administering to a skin region of an animal subject (1) a said skin exfoliant ingredient and (2) an anti-irritant amount of aqueous-soluble divalent calcium cation in a topical vehicle, wherein said skin exfoliant ingredient is administered before, during or after administering said aqueous-soluble divalent cation.
A kit for use in performing topical skin exfoliation of an animal subject, comprising:
- a skin exfoliant formulation comprising a topical vehicle and a skin exfoliant irritant ingredient contained in an amount capable of inducing skin irritation and effecting exfoliation of the skin of said subject;
- an anti-irritant formulation for inhibiting skin irritation attributable to said skin exfoliant irritant ingredient, said anti-irritant formulation comprising an anti-irritant amount of aqueous-soluble divalent calcium cation and a topical vehicle;
- and said anti-irritant formulation further being packaged with instructions directing the topical administration of said anti-irritant formulation before, with or following the topical administration of said skin exfoliant formulation.
Dependencies are inferred from the claim text.