Viral vaccines
AssigneeRhone Merieux
InventorsLouis Joseph Norman Ross, Simon David Scott, Matthew McKinley Binns
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Abstract
A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.
Claims12
A vaccine against Marek's Disease, comprising a vector which contains a DNA fragment encoding the gH gene from MDV serotype 1 or 2 or 3.
DNA fragment comprising the nucleotide sequence of FIG. 14 from nucleotide 3115.
Dependencies are inferred from the claim text.