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AssigneeResearch Corporation Technologies, Inc.
InventorHelena P. Selawry
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A method of treating a disease is provided that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce the biological factor. A method of treating diabetes mellitus is carried out by transplanting pancreatic islet of Langerhans cells in conjunction with Sertoli cells to create an immunologically privileged site. A method of creating an immunologically privileged site and providing cell stimulatory factors in a mammal for transplants is also carried out. A method of co-localizing islet cells with Sertoli cells and the use of the co-localized product for treating diabetes mellitus is further provided. Further described is a method of creating systemic tolerance to foreign antigens. A method of enhancing the viability, maturation, proliferation of functional capacity of cells in tissue culture is also provided. In addition, a pharmaceutical composition comprising Sertoli cells and cells that produce a biological factor is provided.
A method of treating a disease that results from a deficiency of a biological factor in a mammal wherein said method comprises administering Sertoli cells obtained from a cell line and a therapeutically effective amount of cells that produce said biological factor to a mammal in need of such treatment, wherein said Sertoli cells are administered in an amount effective to create an immunologically privileged site.
A method of treating diabetes mellitus in a mammal wherein said method comprises administering to a diabetic mammal Sertoli cells obtained from a cell line in an amount effective to create an immunologically privileged site and a therapeutically effective amount of pancreatic islet of Langerhans cells.
A method of treating an autoimmune disease in a mammal wherein said method comprises transplanting in to said mammal a therapeutically effective amount of isolated Sertoli cells obtained from a cell line to a transplant site in said mammal having said autoimmune disease, wherein said site is other than testes.
A method of enhancing the recovery and proliferation of ex vivo cells comprising co-culturing said cells with Sertoli cells for a time and under conditions sufficient to achieve said enhanced recovery and proliferation.
A method of enhancing the recovery and proliferation of ex vivo cells comprising culturing said cells in a tissue culture medium containing Sertoli cells for a time and under conditions sufficient to achieve said enhanced recovery and proliferation.
A method of treating a disease that results from a deficiency of a biological factor in a mammal wherein said method comprises administering Sertoli cells and a therapeutically effective amount of cells that produce said biological factor to a mammal in need of such treatment, wherein said Sertoli cells are administered in an amount effective to create an immunologically privileged site;
Dependencies are inferred from the claim text.