Loading patent…
AssigneeResearch Development Foundation
InventorsJ. Clifford Waldrep, Vernon Knight, Melanie B. Black
Estimating the term…
The present invention provides a high dose pharmaceutical liposome aerosol composition comprising about 12-30 mg/ml of a pharmaceutical compound, and about 130-375 mg of a phospholipid/ml starting reservoir concentration. Specifically, the present invention is drawn to anti-inflammatory glucocorticoids, immunosuppressive compounds, anti-fungal compounds, antibiotic compounds, anti-viral compounds, and anti-cancer compounds delivered via a high dose liposome aerosol composition in a phospholipid. More specifically, the invention provides a high dose cyclosporin A liposome aerosol composition comprising up to about 30 mg/ml cyclosporin A in up to about 225 mg of a phospholipid/ml starting reservoir concentration. Also provided is a high dose budesonide-liposome aerosol composition comprising up to about 15 mg/ml budesonide in up to about 225 mg of a phospholipid/ml starting reservoir concentration.
A high dose cyclosporin A liposome aerosol composition comprising about 5 mg/ml to about 30 mg/ml cyclosporin A and about 37.5 mg to about 225 mg of a phospholipid/ml starting reservoir concentration.
A high dose budesonide-liposome aerosol composition comprising about 1 mg/ml to about 15 mg/ml budesonide in about 15 mg to about 225 mg of a phospholipid/ml starting reservoir concentration, wherein a particle size of said liposome as measured by mass median aerodynamic diameter is in the range of from about 1.0 .mu.m to about 3.0 .mu.m.
A high dose cyclosporin A liposome aerosol composition comprising about 5 mg/ml to about 21.3 mg/ml cyclosporin A in about 37.5 mg to about 160 mg of dilauroylphosphatidylcholine/ml starting reservoir concentration.
A high dose budesonide-liposome aerosol composition comprising about 1 mg/ml to about 12.5 mg/ml budesonide in about 15 mg to about 187.5 mg of dilauroylphosphatidylcholine/ml starting reservoir concentration, wherein a particle size of said liposome as measured by mass median aerodynamic diameter is in the range of from about 1.0 .mu.m to about 3.0 .mu.m.
Dependencies are inferred from the claim text.