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US 5,958,372 AGranted
Low viscosity chelating polymers for diagnostic imaging
AssigneeNycomed Imaging AS
InventorDavid L. Ladd
Life of this patent
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Abstract
Disclosed are linear and cross-linked polymers suitable for use as a contrast agent for magnetic resonance imaging containing units comprising the residue of a poly(amine) moiety linked to a chelating agent and to one or more pendant (poly)alkylene oxides.
Claims12
A polymer comprising polymer repeating units of formula (I):
- ##STR10## wherein R=H or an alkyl group;
- R'=H, alkyl, aralkyl or --PAO--OR;
- PAO=a polyalkylene oxide of MW 200-20,000;
- metal=a paramagnetic or radioactive metal;
- chelator=the residue of a chelating agent.;
- y-1-10;
- x=2-1000;
- L=a carbon, amino, imido, nitrilo, imino, alkylene, carbonyl, sulfonyl, sulfinyl, ether, thioether, ester, thioester, amide, thioamide, thio, dithio, phosphate, phosphonate, urelene, thiourelene, urethane, thiourethane, an amino acid linkage, or a peptide linkage;
- and
- R"=a bond or an alkylene group optionally interrupted by one or more nitrogen or sulfur heteroatoms.
7 more elements
Dependencies are inferred from the claim text.