Electropipettor and compensation means for electrophoretic bias
AssigneeCaliper Technologies Corp.
InventorsJ. Wallace Parce, Michael R. Knapp
Life of this patent
Estimating the term…
Loading patent…
AssigneeCaliper Technologies Corp.
InventorsJ. Wallace Parce, Michael R. Knapp
Estimating the term…
The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.
A microfluidic system, comprising:
A microfluidic device having at least first and second intersecting fluid channels disposed therein, said first channel having an aspect ratio (width:depth) that is greater than about 5, and wherein the first and second channels comprise different depths.
A microfluidic system comprising:
A microfluidic system comprising:
A microfluidic system comprising:
A method of electrokinetically transporting a material stream through a first microscale channel, wherein the first channel is intersected by a second channel and the material stream comprises at least first and second material regions of differing ionic concentrations, comprising:
Dependencies are inferred from the claim text.