Non-thrombogenic coating composition and methods for using same
AssigneeInnerdyne, Inc.
InventorsRay Tsang, Shigemasa Osaki
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Abstract
The present invention provides an anti-thrombogenic coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: ##STR1## wherein R.sub.1 is a C.sub.1-8 alkyl or C.sub.6-32 aryl group, each R.sub.2 is independently selected from the group consisting of C.sub.1-8 alkyl and C.sub.6-32 aryl, R.sub.3 is N or O, and n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding.
Claims28
A non-thrombogenic coating composition for blood-contacting surfaces, said composition comprising a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I:
- ##STR7## wherein R.sub.1 is a C.sub.1-8 alkyl or C.sub.6-32 aryl group,
- each R.sub.2 is independently selected from the group consisting of C.sub.1-8 alkyl and C.sub.6-32 aryl
- R.sub.3 is N or O, and
- n is a number from 1 to 10 directly bound to sodium heparin via covalent bonding.
A non-thrombogenic medical device comprising surfaces for contacting blood, said surfaces having coated thereon a non-thrombogenic coating composition comprising a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I:
- ##STR8## wherein R.sub.1 is a C.sub.1-8 alkyl or C.sub.6-32 aryl group,
- each R.sub.2 is independently selected from the group consisting of C.sub.1-8 alkyl and C.sub.6-32 aryl,
- R.sub.3 is N or O, and
- n is a number from 1 to 10 directly bound to heparin via covalent bonding.
A method for rendering blood-contacting surfaces of a medical device non-thrombogenic, said method comprising coating said surfaces with a non-thrombogenic coating composition comprising a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I:
- ##STR9## wherein R.sub.1 is a C.sub.1-8 alkyl or C.sub.6-32 aryl group,
- each R.sub.2 is independently selected from the group consisting of C.sub.1-8 alkyl and C.sub.6-32 aryl,
- R.sub.3 is N or O, and
- n is a number from 1 to 10 directly bound to heparin via covalent bonding.
Dependencies are inferred from the claim text.