Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
AssigneeQueen's University at Kingston
InventorsJames C. Kennedy, Roy H. Pottier, Robert L. Reid, Arnold Sac-Morales, Lewis L. Tomalty
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Abstract
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.
Claims12
A method for treating acne, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to a patient in need of such treatment, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.
A method for treating a patient suffering from a disorder associated with a Propinobacterium, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to said patient, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.
A method for treating malaria, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to a patient in need of such treatment, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.
A method for treating a patient suffering from a disorder associated with the presence of a parasite selected from the group consisting of Plasmodium falciparum, Plasmodium ovale, Plasmodium malaria, and Plasmodium vivax, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to said patient, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.
A method for treating a skin lesion that is associated with the presence of a bacterium, comprising administering a therapeutically effective amount of a precursor of protoporphyrin IX to a patient in need of such treatment, and thereafter exposing the patient to light capable of photoactiviating protoporphyrin IX.
Dependencies are inferred from the claim text.