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US 5,955,476 AGranted
Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
AssigneeCelgene Corporation
InventorsGeorge W. Muller, David I. Stirling, Roger Shen-Chu Chen, Hon-Wah Man
Life of this patent
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Abstract
1-Oxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3 -yl)-isoindoline.
Claims23
A method of reducing or inhibiting undesirable levels of inflammatory cytokines in a mammal, which comprises:
- administering thereto an effective amount of a compound selected from the group consisting of
- (a) a 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline of the formula:
- ##STR5## in which Y is oxygen or H.sub.2 and
- each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, independently of the others, is hydrogen, halo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or amino, and
- (b) the acid addition salts of said 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines which contain a nitrogen atom capable of being protonated.
2 more elements
Dependencies are inferred from the claim text.