Antisense oligonucleotides to human serine/threonine protein phosphatase genes
AssigneesSouth Alabama Medical Science Foundation, Isis Pharmaceuticals, Inc.
InventorsRichard E. Honkanen, Nicholas M. Dean
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Abstract
Oligonucleotides are provided which are targeted to nucleic acids encoding human serine/threonine protein phosphatases and which are capable of inhibiting protein phosphatase expression. Methods of inhibiting the expression of human protein serine/threonine phosphatases using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal conditions, including cancer, using oligonucleotides of the invention.
Claims11
An oligonucleotide about 8 to 50 nucleotides in length which is targeted to a nucleic acid encoding a human serine/theonine protein phosphatase and which inhibits protein phosphatase expression, wherein the oligonucleotide is targeted to a translation initiation site, coding region, or 3' untranslated region of mRNA encoding a human serine/theonine protein phosphatase and wherein the oligonucleotide is targeted to mRNA encoding protein phosphatase 5, protein phosphatase 4, or protein phosphatase 1.gamma.1.
Dependencies are inferred from the claim text.