Recombinant canine brain natriuretic peptide

Abstract

Peptides of the formula R.sup.1 -Cys-Phe-Gly-Arg-Arg-Leu-Asp-Arg-Ile-Gly-Ser-Leu-Ser-Gly-Leu-Gly-Cys-R.sup .2 wherein R.sup.1 is selected from the group consisting of: (H); Gly-; Ser-Gly-; Lys-Ser-Gly-; His-Lys-Ser-Gly-; Met-His-Lys-Ser-Gly-; Thr-Met-His-Lys-Ser-Gly-; Lys-Thr-Met-His-Lys-Ser-Gly-; Pro-Lys-Thr-Met-His-Lys-Ser-Gly-; Ser-Pro-Lys-Thr-Met-His-Lys-Ser-Gly-; or is the amino acid sequence of the dog prepro sequence upstream of position 100 shown in FIG. 8 herein or a C-terminal portion thereof; R.sup.2 is (OH), NH.sub.2, or NR.sub.2 wherein each R is independently H or lower alkyl (1-4C) or is Asn; Asn-Val; Asn-Val-Leu; Asn-Val-Leu-Arg; Asn-Val-Leu-Arg-Lys; Asn-Val-Leu-Arg-Lys-Tyr; or the amides thereof are useful in treating conditions characterized by high levels of extracellular fluid.

Dependencies are inferred from the claim text.