Apparatus and polymeric endoluminal sealing
AssigneeEndoluminal Therapeutics, Inc.
InventorsMarvin J. Slepian, Anton Schindler
Life of this patent
Estimating the term…
Abstract
A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.
Claims94
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an article-forming element at the distal end of the shaft;
- a polymeric article positioned on the article-forming element that is formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- and
- a source of temperature control in thermal communication with the polymeric article.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an article-forming element at the distal end of the shaft;
- and
- a polymeric article positioned on the article-forming element that is formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient,
- wherein the polymeric article is non-fluent at normal patient temperature, becomes fluent when its temperature is altered from normal patient temperature to an application temperature, and becomes non-fluent when its temperature returns from the application temperature to normal patient temperature.
Catheter apparatus as claimed in 21, wherein the temperature-controlled fluid comprises a fluid at a temperature greater than that of normal patient temperature.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an article-forming element at the distal end of the shaft;
- a polymeric article positioned on the article-forming element that is formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- and
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end, wherein the article-forming element comprises a radially-expandable balloon disposed on the shaft in alignment with the lumen and is in fluid communication via the lumen with a source of pressurized fluid, the polymeric article is non-fluent at normal patient temperature, becomes fluent at an application temperature that is greater than normal patient temperature, and becomes non-fluent when its temperature returns from the application temperature to normal patient temperature, and the apparatus further comprises a source of heated fluid in fluid communication with the polymeric article.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element at the distal end of the shaft;
- and
- a polymeric article positioned on the article-forming element that is formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article and wherein the article is made of a material selected from the group consisting of polymers of carboxylic acids, polyurethanes, polyesters, polyamides, polyacrylonitriles, polyphosphazines, polylactones, polyanhydrides, polyethylenes, polyvinyl chlorides, ethylene vinyl acetate, delta-valerolactone, and p-dioxanone.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element at the distal end of the shaft;
- and
- a polymeric article that contains a therapeutic agent positioned on the article-forming element, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element at the distal end of the shaft;
- and
- a polymeric article that contains living cells, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the article-forming element,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element at the distal end of the shaft;
- and
- a polymeric article, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the article-forming element,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article and the polymeric article is non-fluent at normal patent temperature, becomes fluent when its temperature is raised above normal patient temperature, and becomes non-fluent when its temperature returns to normal patient temperature.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- a radially expandable article-forming element at the distal end of the shaft;
- a polymeric article, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the article-forming element wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article;
- and
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end, wherein the radially expandable article-forming element is connected via the lumen to a source of pressurized fluid.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a radially expandable balloon at the distal end of the shaft;
- a polymeric article, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the balloon;
- and
- an emitter of electromagnetic radiation near the distal end of the shaft positioned in optical communication with the polymeric article.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end;
- a reservoir of pre-polymer fluid in fluid communication with the distal end of the shaft via the lumen that is formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- and
- a heat source in thermal communication with the distal end of the shaft.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end;
- a reservoir of pre-polymer fluid in fluid communication with the distal end of the shaft via the lumen that is formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- and
- an emitter of electromagnetic radiation near the distal end of the shaft.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end;
- a reservoir of pre-polymer fluid in fluid communication with the distal end of the shaft via the lumen, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- a radially-expandable occlusion element near the distal end of the shaft;
- and
- a molding element near the distal end of the shaft.
Catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end;
- a reservoir of pre-polymer fluid in fluid communication with the distal end of the shaft via the lumen, formable into a layer of biodegradable polymeric material in intimate and conforming contact with an irregularly contoured tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- a radially-expandable proximal occlusion element near the distal end of the shaft and a radially-expandable distal occlusion element on the shaft positioned distally relative to the proximal occlusion element.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising a tubular body having proximal and distal ends, which tubular body defines a lumen divided into a plurality of sublumens, each sublumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each sublumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, wherein at least one of said sublumens is connected to a reservoir containing a monomer or pre-polymer-containing liquid, whereby the biodegradable polymeric coating is formed by delivering the monomer or pre-polymer-containing liquid through the sublumen to the tissue lumen, and wherein the device includes two occluding balloons, one disposed toward the proximal end of the tubular body from the aperture of the sublumen which is connected to the reservoir, and the other disposed toward the distal end of the tubular body from the aperture of the sublumen which controls delivery of polymeric coating material, whereby the occluding balloons together act to at least partially occlude a portion of the tissue lumen.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising biodegradable polymer coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each lumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, the catheter constructed and arranged such that fluid flow through at least one of said lumens can control delivery of the biodegradable polymeric coating material to the tissue lumen, wherein the device includes two occluding balloons, one disposed toward the proximal end of the tubular body from the aperture of the lumen which controls delivery of polymeric coating material, and the aperture toward the distal end of the tubular body from the aperture of the lumen which controls delivery of polymeric coating material, whereby the occluding balloons together act to at least partially occlude a portion of the tissue lumen.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising biodegradable polymer coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each lumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, the catheter constructed and arranged such that fluid flow through at least one of said lumens can control delivery of the biodegradable polymeric coating material to the tissue lumen, wherein an expansible member is disposed around the tubular body in alignment with the aperture of the lumen that controls polymer delivery, whereby fluid flow through the lumen that controls polymer delivery inflates the expansible member, and wherein a partial or complete layer of polymeric coating material is disposed around the expansible member, whereby expansion of the balloon causes the polymeric material to coat the tissue lumen.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising biodegradable polymer coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each lumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, the catheter constructed and arranged such that fluid flow through at least one of said lumens can control delivery of the biodegradable polymeric coating material to the tissue lumen, wherein the device includes a heating element, whereby the polymeric coating material can be heated prior or subsequent to delivery to the tissue lumen.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising biodegradable polymer coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each lumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, the catheter constructed and arranged such that fluid flow through at least one of said lumens can control delivery of the biodegradable polymeric coating material to the tissue lumen, wherein the device includes an optical fiber whereby light can be delivered to the polymeric coating material.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising biodegradable polymer coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each lumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, the catheter constructed and arranged such that fluid flow through at least one of said lumens can control delivery of the biodegradable polymeric coating material to the tissue lumen, wherein the device includes a mechanically retractable protective sheath.
A catheter device for application of a biodegradable polymeric coating material to a tissue lumen comprising biodegradable polymeric coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens, each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connected to at least one aperture in the tubular body, each lumen forming a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, wherein at least one lumen is constructed and arranged to allow the biodegradable polymeric coating material to be reconfigured in the tissue lumen by a fluid flowed through said at least one lumen, wherein the device includes two occluding balloons, one disposed toward the proximal end of the tubular body from the aperture of the lumen which controls delivery of polymeric coating material, and the other disposed toward the distal end of the tubular body from the aperture of the lumen which controls delivery of polymeric coating material, whereby the occluding balloons together act to at least partially occlude a portion of the tissue lumen.
A catheter device for application of a biodegradable polymeric coating material to a tissue lumen comprising biodegradable polymeric coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens, each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connected to at least one aperture in the tubular body, each lumen forming a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, wherein at least one lumen is constructed and arranged to allow the biodegradable polymeric coating material to be reconfigured in the tissue lumen by a fluid flowed through said at least one lumen, wherein the device includes a heating element, whereby the polymeric coating material can be heated prior or subsequent to delivery to the tissue lumen.
A catheter device for application of a biodegradable polymeric coating material to a tissue lumen comprising biodegradable polymeric coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens, each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connected to at least one aperture in the tubular body, each lumen forming a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, wherein at least one lumen is constructed and arranged to allow the biodegradable polymeric coating material to be reconfigured in the tissue lumen by a fluid flowed through said at least one lumen, wherein the device includes an optical fiber whereby light can be delivered to the polymeric coating material.
A catheter device for application of a biodegradable polymeric coating to a tissue lumen comprising biodegradable polymer coating material and a tubular body having proximal and distal ends, which tubular body defines a plurality of lumens each lumen extending from the proximal end of the tubular body toward the distal end of the tubular body and connecting to at least one aperture in the tubular body whereby each lumen forms a conduit for fluid flow between at least one aperture in the tubular body and the proximal end of the tubular body, the catheter constructed and arranged such that fluid flow through at least one of said lumens can control delivery of the biodegradable polymeric coating material to the tissue lumen, wherein the distal aperture of the lumen is constructed and arranged to provide flow acceleration and shaped to provide sprayed application.
Dependencies are inferred from the claim text.