Inhibitors of p38

A compound of the formula:

• ##STR38## wherein:
• each of Q.sub.1 and Q.sub.2 are independently selected from phenyl or pyridyl;
• wherein:
• Q.sub.1 is substituted with 1 to 4 substituents, independently selected from halo;
• C.sub.1 -C.sub.3 alkyl;
• C.sub.1 -C.sub.3 alkyl substituted with NR', OR', CO.sub.2 R' or CONR'.sub.2 ;
• O--(C.sub.1 -C.sub.3)-alkyl;
• O--(C.sub.1 -C.sub.3)-alkyl substituted with NR', OR', CO.sub.2 R' or CONR'.sub.2 ;
• NR'.sub.2 ;
• OCF.sub.3 ;
• CF.sub.3 ;
• NO.sub.2 ;
• CO.sub.2 R';
• CONR';
• SR';
• SCF.sub.3 ;
• or CN;
• and
• Q.sub.2 is optionally substituted with up to 4 substituents, independently selected from halo;
• C.sub.1 -C.sub.3 alkyl;
• C.sub.1 -C.sub.3 alkyl substituted with NR', OR', CO.sub.2 R' or CONR'.sub.2 ;
• O--(C.sub.1 -C.sub.3)-alkyl;
• O--(C.sub.1 -C.sub.3)-alkyl substituted with NR', OR', CO.sub.2 R' or CONR'.sub.2 ;
• NR'.sub.2 ;
• OCF.sub.3 ;
• CF.sub.3 ;
• NO.sub.2 ;
• CO.sub.2 R';
• CONR';
• SR';
• SCF.sub.3 ;
• or CN;
• wherein R' is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl or (C.sub.2 -C.sub.3)-alkenyl or alkynyl;
• X is selected from --S--, --O--, --S(O.sub.2)--, --S(O)--, --S(O.sub.2)--N(R)--, --N (R) --S(O.sub.2)--, --N(R)--C(O)O--, --O--C(O)--N(R)--, --C(O)--, --C(O)O--, --O--C(O)--, --C(O)--N(R)--, --N(R) --C(O)--, --N(R)--, or --C(R.sub.2)--;
• each R is independently selected from hydrogen, --R.sup.2, --NR.sup.2.sub.2, --OR.sup.2, SR.sup.2, --C(O)--NR.sup.2.sub.2 or --C(O)--OR.sup.2 wherein two adjacent R are optionally bound to one another and, together with each Y to which they are respectively bound, form a 4-8 membered carbocyclic or heterocyclic ring;
• R.sup.2 is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl, O--(C.sub.2 -C.sub.3)-alkyl, (C.sub.1 -C.sub.3)-alkenyl or O--C(C.sub.2 -C.sub.3)-alkenyl, each optionally substituted with W;
• W is selected from --N(R').sub.2, --OR', --SR', --S(O)R', --S(O.sub.2)R', C(O)OR', ##STR39## or any 5 to 7-membered heterocyclic ring comprising up to 3 heteroatoms independently selected from N, O or S, wherein said heterocyclic ring is optionally substituted with up to 3 substituents independently selected from halo, C.sub.1 -C.sub.3 alkyl, O--(C.sub.1 -C.sub.3)-alkyl, NR'.sub.2, OCF.sub.3, CF.sub.3, NO.sub.2, CO.sub.2 R', CONR' or CN;
• Y is C;
• A is N;
• n is 1 and
• R.sub.1 is selected from hydrogen, (C.sub.1 -C.sub.3)-alkyl, OH, or O--(C.sub.1 -C.sub.3)-alkyl.