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US 5,945,126 AGranted
Continuous microsphere process
AssigneeOakwood Laboratories, LLC
InventorsBagavathikanun Chithambara Thanoo, James Murtagh
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Abstract
A continuous process for producing microspheres wherein small particle sizes can be obtained without the problem of foaming. A drug and polymer containing dispersed phase is continuously introduced into a high intensity emulsification vessel along with a continuous phase. An emulsion of the dispersed phase is formed in the continuous phase by high intensity mixing effective to quickly solidify the dispersed phase polymer without having to take steps to address foaming.
Claims26
A continuous method of making active agent containing polymer bodies comprising:
- a) forming a dispersed phase comprising active agent and polymer;
- b) providing a continuous phase in which said dispersed phase will form an emulsion;
- c) continuously introducing dispersed phase into a reactor vessel at a dispersed phase feed rate, and continuous phase into said reactor vessel at a continuous phase feed rate, said reactor vessel including means for forming an emulsion, and forming an emulsion of said dispersed phase in said continuous phase;
- d) continuously transporting said emulsion from said reactor vessel to a solvent removal vessel to remove solvent.
1 more element
Dependencies are inferred from the claim text.