CD44-like protein and nucleic acids
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Reiner L. Gentz, Patrick J. Dillon
Life of this patent
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Abstract
The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.
Claims87
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids from about -21 to about 301 of SEQ ID NO:2;
- (b) a polynucleotide encoding amino acids from about -20 to about 301 of SEQ ID NO:2;
- (c) a polynucleotide encoding amino acids from about 1 to about 301 of SEQ ID NO:2;
- (d) a polynucleotide encoding the same polypeptide encoded by the cDNA contained in ATCC Deposit No. 97520;
- (e) a polynucleotide encoding the same mature CD44-like polypeptide encoded by the cDNA contained in ATCC Deposit No. 97520;
- (f) a polynucleotide encoding amino acids from about 1 to about 217 of SEQ ID NO:2;
- (g) a polynucleotide encoding amino acids from about 246 to about 301 of SEQ ID NO:2;
- (h) a polynucleotide encoding amino acids from about 1 to about 217 and about 246 to about 301 of SEO ID NO:2;
- (i) the polynucleotide complement of the polynucleotide of (a), (b), (c), (d), (e), (f), (g), or (h);
- and
- (j) a polynucleotide at least 95% identical to the polynucleotide of (a), (b), (c), (d), (e), (f), (g), (h), or (i).
An isolated nucleic acid molecule comprising 500 contiguous nucleotides from the coding region of SEQ ID NO:1.
An isolated nucleic acid molecule comprising a polynucleotide encoding a CD44-like polypeptide wherein, except for at least one conservative amino acid substitution, said polypeptide has an amino acid sequence selected from the group consisting of:
- (a) amino acids -21 to 301 of SEQ ID NO:2;
- (b) amino acids -20 to 301 of SEQ ID NO:2;
- (c) amino acids 1 to 301 of SEQ ID NO:2;
- (d) amino acids 1 to 217 of SEQ ID NO:2;
- and
- (e) amino acids 246 to 301 of SEQ ID NO:2.
An isolated polypeptide comprising amino acids at least 95% identical to amino acids selected from the group consisting of:
- (a) amino acids from about -21 to about 301 of SEQ ID NO:2;
- (b) amino acids from about -20 to about 301 of SEQ ID NO:2;
- (c) amino acids from about 1 to about 301 of SEQ ID NO:2;
- (d) amino acids from about 1 to about 217 of SEQ ID NO:2;
- (e) amino acids from about 246 to about 301 of SEQ ID NO:2;
- and
- (f) amino acids from about 1 to about 217 and about 246 to about 301 of SEQ ID NO:2.
An isolated CD-44 like polypeptide wherein, except for at least one conservative amino acid substitution, said polypeptide has an amino acid sequence selected from the group consisting of:
- (a) amino acids from about -21 to about 301 of SEQ ID NO:2;
- (b) amino acids from about -20 to about 301 of SEQ ID NO:2;
- (c) amino acids from about 1 to about 301 of SEQ ID NO:2;
- (d) amino acids from about 1 to about 217 of SEQ ID NO:2;
- (e) amino acids from about 246 to about 301 of SEQ ID NO:2;
- and
- (f) amino acids from about 1 to about 217 and about 246 to about 301 of SEO ID NO:2.
An isolated polypeptide comprising amino acids selected from the group consisting of:
- (a) amino acids -21 to 301 of SEQ ID NO:2;
- (b) amino acids -20 to 301 of SEQ ID NO:2;
- (c) amino acids 1 to 301 of SEQ ID NO:2;
- (d) amino acids 1 to 217 of SEQ ID NO:2;
- (e) amino acids 246 to 301 of SEQ ID NO:2;
- and
- (f) amino acids from about 1 to about 217 and about 246 to about 301 of SEO ID NO:2.
An isolated polypeptide having an amino acid sequence identical to that encoded by the cDNA contained in ATCC Deposit No. 97520.
An epitope-bearing portion of the CD-44 like polypeptide of SEQ ID NO:2.
Dependencies are inferred from the claim text.