Recombinant poxvirus compositions and methods of inducing immune responses
AssigneeHealth Research, Inc.
InventorEnzo Paoletti
Life of this patent
Estimating the term…
Abstract
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFN.gamma.; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
Claims15
A recombinant poxvirus comprising exogenous DNA encoding an antigenic determinant of a pathogen wherein the antigenic determinant is expressed in a host when the poxvirus is administered to the host.
A composition for inducing an immunological response in a host comprising a recombinant poxvirus wherein the recombinant poxvirus comprises exogenous DNA encoding an antigenic determinent of a pathogen which is expressed in vivo in the host when the composition is administered to the host and an immunological response to the antigenic determinant is induced in the host.
A method for inducing an immunological response in a host comprising administering a recombinant poxvirus to the host, wherein the poxvirus comprises exogenous DNA encoding an antigenic determinant of a pathogen which is expressed in vivo in the host when the composition is administered to the host and an immunological response to the antigenic determinant is induced in the host.
Dependencies are inferred from the claim text.