Localized intravascular delivery of growth factors for promotion of angiogenesis
AssigneesLocalmed, Inc., Beth Israel Deaconess Medical Center, Inc.
InventorsAaron V. Kaplan, Michael Simons
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Abstract
Angiogenesis in cardiac and other tissues is promoted by the transmural delivery of angiogenic factors such as VEGF, FGF, EGF, and PDGF, through blood vessels and other body lumens into the surrounding tissue. Usually, the angiogenic factor is delivered using a catheter having infusion parts at its distal end. Optionally, the distal end of the catheter is radially expanded to engage the infusion parts directly against the blood vessel wall.
Claims24
A method for promoting angiogenesis in tissue surrounding a body lumen, said method comprising transmurally delivering an angiogenic factor at a target site within the body lumen.
A method for promoting angiogenesis in tissue surrounding a blood vessel, said method comprising:
- advancing a distal end of a catheter to a target site within the blood vessel;
- and
- delivering through the distal end of the catheter and transmurally through the blood vessel wall an amount of an angiogenic factor sufficient to promote angiogenesis in tissue surrounding the target site.
A method for promoting angiogenesis in tissue surrounding a stenotic region in a coronary artery, said method comprising:
- advancing transluminally a distal end of an infusion catheter to the stenotic region in the artery;
- radially expanding an array of infusion ports on the distal end of the infusion catheter to engage said ports against the luminal wall of the blood vessel;
- and
- delivering through the infusion ports into the blood vessel wall an amount of an angiogenic factor sufficient to promote angiogenesis in tissue surrounding the target site.
Dependencies are inferred from the claim text.