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US 5,939,405 AGranted
Phosphate derivatives of diaryl 1,3,4-oxadiazolone
AssigneeBristol-Myers Squibb Company
InventorsJohn E. Starrett, Jr., Piyasena Hewawasam, Dalton King
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Abstract
The present invention provides novel phosphate derivatives having the general formula wherein A, R.sup.1 and R.sup.2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.
Claims9
A compound of the formula ##STR19## wherein A is a direct bond, --CHRO-- or ##STR20## n is 0 or 1;
- R is hydrogen or C.sub.1-4 alkyl;
- and
- R.sup.1 and R.sup.2 each are independently hydrogen or a physiologically hydrolyzable group;
- or a nontoxic pharmaceutically acceptable salt or solvate thereof.
1 more element
Dependencies are inferred from the claim text.