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US 5,939,323 AGranted
Hyaluronan based biodegradable scaffolds for tissue repair
AssigneeBrown University
InventorsRobert F. Valentini, Hyun D. Kim
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Abstract
A hyaluronic acid derivitized scaffold and method of forming are disclosed. The scaffolds are useful for various medical purposes such as tissue repair, tissue reconstruction and wound healing. In order to enhance these processes the scaffolds may be engineered to incorporate biologically active molecules such as BMP.
Claims8
A method for forming a substrate having interconnected pores for cell growth, comprising:
- dissolving a water-insoluble ester derivative of hyaluronic acid in a first solvent,
- forming a mixture of the first solvent, the water-insoluble ester derivative of hyaluronic acid and a pore forming agent that is insoluble in the first solvent,
- contacting the mixture with a second solvent, wherein the water-insoluble ester derivative of hyaluronic acid is insoluble in the second solvent but the pore forming agent is soluble in the second solvent, whereby the first solvent and the pore forming agent are extracted from the mixture to form a porous scaffold of the water-insoluble ester derivative of hyaluronic acid, and
- drying the scaffold under vacuum from a wet state at a temperature between 4.degree. C. and 37.degree. C.
1 more element
Dependencies are inferred from the claim text.