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US 5,936,128 AGranted
5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
AssigneeWarner-Lambert Company
InventorsEdmund Lee Ellsworth, Elizabeth Lunney, Bradley Dean Tait
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Abstract
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
Claims1
The compounds named:
- 2-Cyclopentylbenzenethiol;
- 3-Methoxy-2-(1-methylethyl)benzenethiol;
- 2-(1,1-Dimethylethyl)-4-methoxybenzenethiol;
- 2-(Cyclopenten-2-yl)benzenethiol;
- 2-Cyclohexylbenzenethiol;
- 2-(1,1-Dimethylethyl)-5-methoxybenzenethiol;
- 2-(1,1-Dimethyl-2-hydroxyethyl)benzenethiol and
- 2-(1,1-Dimethylethyl)-4,5-(methylenedioxy)benzenethiol.
5 more elements
Dependencies are inferred from the claim text.