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US 5,935,579 AGranted
AIDS therapy and vaccine
AssigneeRetroscreen Ltd.
InventorsJohn Anthony Habeshaw, Angus George Dalgleish, Elizabeth Hounsell, Lynne Bountiff
Life of this patent
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Abstract
The present invention provides therapy and prophylaxis against HIV-induced AIDS, as well as methods for ascertaining the susceptibility of an individual to HIV-induced AIDS, the invention being based on the discovery that AIDS results from gp120 of HIV mimicking the antigen-presenting component of the immune system, thereby spuriously activating certain CD4+ T cells in susceptible individuals, leading to a condition similar to graft versus host disease, the condition being treatable by eliminating the responsible T cells, for example.
Claims9
A peptide consisting of:
- T R A K R R V V E R E K R (SEQ ID No. 4)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T R A K R R V V Q R E K R (SEQ ID No. 29)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T K A K R R V V E R E K R (SEQ ID No. 1)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T K A K R R V V Q R E K R (SEQ ID No. 27)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T K A K R A V V E R E K R (SEQ ID No. 20)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T R A K R R V V E R E K R A (SEQ ID No. 32)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T K A K R R V V E R E K R A (SEO ID No. 31)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
A peptide consisting of:
- T K A K R A V V E R E K R A (SEQ ID No. 20)
- wherein said peptide will stimulate proliferation of a T-cell clone in a T-cell proliferation assay and wherein said peptide will produce an alloepitopic effect in a second T-cell assay comprising said stimulated T-cell clone such that said T-cell clone proliferates and further wherein said peptide when administered in a tolerizing amount will suppress proliferation of said T-cell clone in said second assay.
An immunogenic composition comprising:
- (a) a peptide selected from the group consisting of:
- T R A K R R V V E R E K R (SEQ ID No. 4)
- T R A K R R V V Q R E K R (SEQ ID No. 29)
- T K A K R R V V E R E K R (SEQ ID No. 1)
- T K A K R R V V Q R E K R (SEQ ID No. 27)
- T K A K R A V V E R E K R (SEQ ID No. 20)
- T R A K R R V V E R E K R A (SEQ ID No. 32)
- T K A K R R V V E R E K R A (SEQ ID No. 31);
- and
- T K A K R A V V E R E K R A (SEQ ID No. 20)
- and;
- (b) an acceptable adjuvant or carrier protein.
9 more elements
Dependencies are inferred from the claim text.