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US 5,932,547 AGranted
Non-aqueous polar aprotic peptide formulations
AssigneeAlza Corporation
InventorsCynthia L. Stevenson, Steven J. Prestrelski
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Abstract
This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non- aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.
Claims34
A stable non-aqueous formulation of a peptide compound comprising:
- a) at least one peptide compound;
- and
- b) at least one polar aprotic solvent,
- wherein said peptide compound is an LHRH-related compound.
1 more element
A stable non-aqueous formulation of a peptide compound comprising:
- a) at least one peptide compound;
- b) at least one polar aprotic solvent;
- and
- c) a non-aqueous protic solvent.
1 more element
A stable non-aqueous formulation of a peptide compound comprising:
- (a) at least one peptide compound;
- and
- (b) at least one polar aprotic solvent,
- wherein said peptide compound is selected from the group consisting of glucagon, glucagon like peptide-1 and glucagon like peptide-2.
1 more element
Dependencies are inferred from the claim text.