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US 5,932,412 AGranted
Synthetic peptides in human papillomaviruses 1, 5, 6, 8, 11, 16, 18, 31, 33 and 56, useful in immunoassay for diagnostic purposes
AssigneeEuro-Diagnostica AB
InventorsJoakim Dillner, Lena Dillner, Hwee-Ming Cheng
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Abstract
The invention refer to a method for diagnosing the presence of infection of papilloma virus (PV) and of papilloma virus (PV) carrying, especially cervix cancer and condyloma, by the detection of virus specific antigen-antibody complexes in immunossay.
Claims5
A method for detecting the presence of human papillomavirus antibody, and papillomavirus associated diseases comprising:
- contacting a sample with a peptide specific for human papillomavirus E7 protein, wherein the peptide is SEQ ID NO:
- 3, 9, 12, 15, 52, 53, 54, 60, 61, 62, 63, 64, 65, 66, 71, 76, 79, 152, 153, 154, 155, 156, 157, 186, or 193;
- detecting a level of peptide binding in said sample;
- comparing said level of peptide binding in said sample to a level of peptide binding in a control sample;
- and
- quantitating said level of peptide binding in said sample, wherein said level of peptide binding in said sample which is greater than said level of peptide binding in said control sample indicates the presence of human papillomavirus antibody and papillomavirus associated diseases.
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Dependencies are inferred from the claim text.