Stereoselective ring opening reactions
AssigneePresident and Fellows of Harvard College
InventorsEric N. Jacobsen, James L. Leighton, Luis E. Martinez
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Abstract
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a stereoisomerically or regioselectively enriched product.
Claims24
A kinetic resolution process which comprises reacting a nucleophile and a racemic mixture of a chiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a stereoisomerically enriched cyclic substrate by kinetic resolution, wherein said cyclic substrate comprises a carbocycle or heterocycle having a reactive center susceptible to nucleophilic attack by said nucleophile, and said chiral catalyst comprises an asymmetric tetradentate ligand complexed with a metal atom, which complex has a rectangular planar or rectangular pyrimidal geometry.
A kinetic resolution process which comprises reacting a nucleophile and a racemic mixture of a chiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a stereoisomerically enriched cyclic substrate by kinetic resolution, wherein said cyclic substrate comprises a carbocycle or heterocycle having a reactive center susceptible to nucleophilic attack by said nucleophile, and said chiral catalyst comprises an asymmetric tridentate ligand complexed with a metal atom, which complex has a planar geometry.
Dependencies are inferred from the claim text.