Block polymer having functional groups at both ends
AssigneeKazunori Kataoka
InventorsKazunori Kataoka, Masao Kato, Yukio Nagasaki, Teruo Okano
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Abstract
The present invention provides a block polymer which has functional groups on its both ends, and which comprises hydrophilic/hydrophobic segments. As for the functional groups on its both ends, the block polymer has amino group, carboxyl group or mercapto group on .alpha.-terminal, and hydroxyl group, carboxyl group, aldehyde group or vinyl group on .omega.-terminal. Hydrophilic segment comprises polyethylene oxide, while hydrophobic segment is derived from lactide, lactone or (meth)acrylic acid ester. The block polymer of this invention forms a polymeric micelle which is usable as bio-compatible materials.
Claims10
A block polymer which is represented by formula (I) below:
- X--O.paren open-st.CH.sub.2 CH.sub.2 O.paren close-st..sub.m .paren open-st.Y.paren close-st..sub.n Z (I)
- wherein X denotes an alkyl group having 1 to 10 carbon atoms which has one or two substituents selected from the group consisting of amino group blocked with amino-protecting group, carboxyl group blocked with carboxyl-protecting group and mercapto group blocked with mercapto-protecting group, or phenyl or phenyl-alkyl group which has the above-mentioned substituents on benzene ring;
- Y denotes a group selected from the group consisting of the following recurring units ##STR122## wherein R.sup.1 and R.sup.2 independently denote hydrogen atom or alkyl group having 1 to 5 carbon atoms;
- R.sup.3 denotes hydrogen atom or methyl group;
- R.sup.4 denotes alkyl group having 1 to 5 carbon atoms which is substituted with hydroxyl group under circumstances;
- q denotes an integer of 2-5;
- Z denotes functional group selected from the group consisting of hydrogen atom, acryloyl group (CH.sub.2 .dbd.CH--CO--), methacryloyl group (CH.sub.2 .dbd.C(CH.sub.3)--CO--), ##STR123## allyl group (CH.sub.2 .dbd.CH--CH.sub.2 --), ##STR124## mercapto group, alkyl group having amino group which is mono- or di-substituted under circumstances with alkyl group having 1 to 5 carbon atoms, alkyl group having carboxyl group or its ester group, alkyl group having aldehyde or its acetal group, and halogen atom;
- and
- m and n independently denote an integer of 2-10,000.
A living block polymer represented by the following formula (II):
- X.sub.a --O.paren open-st.CH.sub.2 CH.sub.2 O.paren close-st..sub.m .paren open-st.Y.paren close-st..sub.n-1 Y.sub.a M.sym. (II)
- wherein Xa denotes an alkyl group having 1 to 10 carbon atoms which has one or two substituents selected from the group consisting of amino group blocked with amino-protecting group, carboxyl group blocked with carboxyl-protecting group and mercapto group blocked with mercapto-protecting group, or denotes a phenyl or phenyl-alkyl group which has the above-mentioned substituents on benzene ring;
- Y and Ya each denote a group selected from the group consisting of groups represented by the following formulae ##STR126## wherein R.sup.1 and R.sup.2 independently denote hydrogen atom or alkyl group having 1 to 5 carbon atoms;
- R.sup.3 denotes hydrogen atom or methyl group;
- R.sup.4 denotes alkyl group having 1 to 5 carbon atoms which is substituted with hydroxyl group under circumstances;
- and q denotes an integer of 2-5;
- M.sup..sym. denotes cation of alkaline metal selected from the group consisting of lithium, sodium, potassium and cesium;
- and
- m and n independently denote an integer of 2-10,000.
Dependencies are inferred from the claim text.