Anti-viral agent prepared by basic and acidic extraction of mangraves
AssigneeMitsui Norin Co., Ltd.
InventorMasatoshi Nakano
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Abstract
An anti-viral agent comprising as the effective component, an alkali extract of mangroves, Momordica charantia, and Aspalathus linearis belonging to Leguminosae family. The effective component is essentially consists of acidic polysaccharides and shows an antioxidant activity and free radical (reactive oxygen species)-scavenging activity. The agent is effective against retrovirus such as human immuno deficiency virus (HIV), with no side-effects on human and/or animals.
Claims19
An anit-viral composition comprising disaccharides and trisaccharides obtained by a process comprising:
- (a) extracting leaves of a mangrove, Momordica charantia L., or Aspalathus linearis belonging to the Leguminosae family with hot water at a temperature of 70 to 100.degree. C. for 30 minutes to 4 hours to obtain residue leaves,
- (b) extracting the residue leaves from step (a) with an alkaline solution to form a crude alkaline extract,
- (c) adding to said crude alkaline extract of step (b) an organic extraction solvent at a concentration of 25-75% (v/v) to obtain acidic polysaccharides containing an uronic acid, a neutral sugar and a reducing sugar, and
- (d) hydrolyzing the acidic polysaccharides from step (c) at a temperature of 75 to 150.degree. C. for 3 to 24 hours with an acid having a concentration of 0.5 to 3N.
A process of producing an anti-viral composition comprising:
- (a) extracting acidic polysaccharides from leaves of a mangrove, Momordica charantia L., or Aspalathus linearis belonging to the Leguminosae family by with hot water at a temperature of 70 to 100.degree. C. for 30 minutes to 4 hours to obtain residue leaves.
- (b) extracting the residue leaves from step (a) with an alkaline solution to form a crude alkaline extract,
- (c) adding to said crude alkaline extract of step (b) an organic extraction solvent of a concentration of 25-75% (v/v) to obtain acidic polysaccharides containing an uronic acid, a neutral sugar and a reducing sugar, and
- (d) hydrolyzing the acidic polysaccharides from step (c) at a temperature of 75 to 150.degree. C. for 3 to 24 hours with an acid having a concentration of 0.5 to 3N.
Dependencies are inferred from the claim text.