Flexible multiple compartment medical container with preferentially rupturable seals

A flexible container for separately storing and mixing liquid diluent and medicament, the container comprising:

• a multi-layer laminate rear sheet including an inner layer of a polypropylene-polyethylene copolymer blended with a styrene ethylene-butylene styrene elastomer, an opaque high-barrier intermediate layer, and an outer high temperature resistant mold release layer;
• a flexible front sheet constructed of a single layer film of a polypropylene-polyethylene copolymer blended with styrene ethylene-butylene styrene elastomer interfacing with the rear sheet, the front sheet sealed to the rear sheet along a common peripheral edge;
• at least two preferentially peelable seals commonly extending from at least one side of the common peripheral edge and separably joining the front and rear sheets to define at least a first compartment containing a liquid medicament;
• and
• a third peelable seal extending between the at least two preferentially peelable seals and joining together their ends opposite the ends extending from the container peripheral edge, the third peelable seal formed parallel to and spaced-away from a second container peripheral edge, the two preferentially peelable seals and the third peelable seal configured to define a compartment containing a liquid diluent, an outlet area and a channel configured to provide fluid communication therebetween.

A flexible container for separately storing and mixing liquid diluent and medicament, the container comprising:

• a multi-layer laminate rear sheet including an inner layer of a polypropylene-polyethylene copolymer blended with a styrene ethylene-butylene styrene elastomer, an opaque high-barrier intermediate layer, and an outer high temperature resistant mold release layer;
• a flexible front sheet constructed of a single layer film of a polypropylene-polyethylene copolymer blended with styrene ethylene-butylene styrene elastomer interfacing with the rear sheet, the front sheet sealed to the rear sheet along a common peripheral edge;
• and
• first and second preferentially peelable seals extending between two parallel sides of the common peripheral edge and separably joining the front and rear sheets to define at least a first compartment containing a liquid medicament, the first and second preferentially peelable seals being rupturable in response to hydraulic pressure developed by manipulating the container, each seal configured with a respective different rupture characteristic such that the first preferentially peelable seal ruptures before the second preferentially peelable seal regardless of whether or not the hydraulic pressure is developed in the medicament compartment.

A flexible container for combined storage and administration of liquid medicaments comprising:

• a flexible rear sheet;
• a flexible front sheet sealed to the rear sheet along a common peripheral edge;
• a peelable seal extending between two sides of the common peripheral edge and separably joining the front and rear sheets to define an outlet compartment and a compartment containing a liquid medicament, wherein the medicament compartment is substantially completely filled with liquid medicament such that there is no gaseous head space in the compartment;
• and
• means, integral to the container, for establishing a meniscus above the liquid medicament when the container is accessed for VI administration.