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US 5,922,914 AGranted
Process to prepare tolterodine
AssigneePharmacia & Upjohn Company
InventorsJames R. Gage, John E. Cabaj
Life of this patent
Estimating the term…
Abstract
Disclosed is a novel intermediate, 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol (IV) ##STR1## and an improved process for the preparation of tolterodine.
Claims6
3,4-Dihydro-6-methyl-4-phenyl-2H-bernzopyran-2-ol (IV).
A process for the production of tolterodine (V) which comprises:
- (1) reducing the lactone (III) ##STR3## with a reducing agent to form the hydroxy compound (IV) ##STR4## and (2) reductively aminating the hydroxy compound (IV) with diisopropylamine.
Dependencies are inferred from the claim text.