Hormone replacement therapy method and hormone dispenser

A hormone replacement therapy method of self-administration by a human female of successive doses of an estrogen and a plurality of successive doses of a progestogen, wherein the female dispenses and self-administers successive individual doses of the estrogen and of the progestogen from containerized sources over a protracted period of time, during which period of time the amount of at least one of which doses is changed, which method comprises the steps of:

• a) dispensing onto a delivery surface from a first containerized source of a first extrudable pharmaceutically acceptable composition containing a plurality of non-discrete doses of the estrogen, a metered volume of the first composition as a single dose of the estrogen;
• b) concurrently dispensing onto the delivery surface, from a second containerized source of a second extrudable pharmaceutically acceptable composition containing a plurality of non-discrete doses of the progestogen, a metered volume of the second composition as a single dose of the progestogen;
• c) transferring the dispensed doses of the first and second compositions from the delivery surface simultaneously to the site of administration of the estrogen and progestogen;
• d) repeating steps a)-c) on a predetermined schedule;
• and
• e) periodically, in response to the physiological symptoms associated with menopause or the hormone replacement therapy currently exhibited by the female, changing the metered volume of at least one of the first and second compositions which is dispensed onto the delivery surface as a single dose thereof.