Soft tissue augmentation material
AssigneeBristol-Myers Squibb Company
InventorWilliam G. Hubbard
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AssigneeBristol-Myers Squibb Company
InventorWilliam G. Hubbard
Estimating the term…
A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.
An implantable or injectable soft tissue augmentation material comprising a matrix of rounded, substantially spherical, biocompatible, substantially non-resorbable, finely divided ceramic particles close to or in contact with each other, said particles having a size distribution in the range from 15 .mu.m to 150 .mu.m.
An injectable implant composition comprising biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 15 .mu.m to 150 .mu.m.
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 15 .mu.m to 150 .mu.m.
A kit comprising:
A method for preparing injectable implant compositions, said method comprising:
An injectable implant composition comprising ceramic particles composed of calcium phosphate mineral and having minimized surface porosity present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 15 .mu.m to 150 .mu.m.
An injectable implant composition comprising biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier in an amount from 15 to 50% by volume of the total composition, wherein the ceramic particles have been size selected to have a size distribution in the range from 15 .mu.m to 150 .mu.m.
An injectable implant composition comprising biocompatible ceramic particles present in a biocompatible organic polymer which will dissipate from a tissue injection site leaving the ceramic particles, wherein the ceramic particles have been size selected to have a size distribution in the range from 15 .mu.m to 150 .mu.m.
An injectable implant composition comprising biocompatible ceramic particles and a biocompatible fluid lubricant, present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 15 .mu.m to 150 .mu.m.
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and a pharmaceutically acceptable fluid carrier wherein the ceramic particles have been treated to minimize surface porosity prior to combining and have been size selected to have a size from 15 .mu.m to 150 .mu.m.
A method for preparing injectable implant compositions, said method comprising combining ceramic particles in a pharmaceutically acceptable fluid carrier in an amount from 15 to 50% by volume of the total composition, wherein the ceramic particles have been size selected to have a size from 15 .mu.m to 150 .mu.m.
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and a biocompatible fluid lubricant in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size from 15 .mu.m to 150 .mu.m.
Dependencies are inferred from the claim text.