Serological assay for herpes
AssigneeAuRx, Inc.
InventorsLaure Aurelian, Gary J. Calton
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Abstract
The present method relates to the serological detection of herpes simplex virus type 2 (HSV-2) infection by means of reaction of a patient serum with a peptide specific to HSV-2 having the sequence Ala-Arg-Ser-Pro-Glu -Arg-Gln-Glu-Pro-Arg-Glu-Pro-Glu. The peptide may be further modified by the addition of a Cys or a biotin molecule. The peptide may be used in any of a number of assays including enzyme linked immunosorbent assay (ELISA), a radioimmunoassay (RIA), and other forms of immunoassay such as enzyme immunoblotting assay on a suitable adsorbent paper or an agglutination assay using the peptide composition as the antigen.
Claims10
A method for detecting antibodies to HSV-2 in a serum sample without detecting antibodies to HSV-1 in such a sample comprising the steps:
- a. contacting the serum with a peptide having the structure of SEQ ID NO:
- 1, and
- b. examining the peptide for the presence of bound antibody.
Dependencies are inferred from the claim text.