Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon
AssigneeLaboratoire European De Biotechnologie S.A.
InventorsPatrick Benoit, Francois Meyer, Debborah Maguire, Ivan Plavec, Michael G. Tovey
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Abstract
A monoclonal antibody directed against the human interferon type I receptor (IFN-R), which recognizes the extracellular domain of the human IFN-R and has neutralizing capacity against the biological properties of human type I-IFN. Diagnostic applications for the monoclonal antibody also are provided.
Claims22
A monoclonal antibody directed against the human interferon type I receptor (IFN-R) characterized by the following properties:
- it recognizes an epitope on the amino acid sequence 27-427 of SEQ ID NOS:
- 1 or 2 or of the human INF-R, and,
- it has a neutralizing capacity in vitro against the antiproliferative or antiviral activity of human type I-IFN.
A monoclonal antibody directed against the human interferon type 1 receptor (IFN-R) wherein said monoclonal antibody recognizes the extracellular domain of the human IFN-R of SEQ ID NO:
- 2 and has a neutralizing capacity in vitro against the biological properties of the human type I-IFN, and wherein said monoclonal antibody is the 64G12 antibody deposited at the ECACC on Feb. 26, 1992 under No. 92022605.
A monoclonal antibody directed against the human interferon class I receptor (IFN-R) wherein said monoclonal antibody recognizes the extracellular domain of the human IFN-R and has a neutralizing capacity against the biological properties of the human type I-IFN, and wherein said monoclonal antibody is the 64G12 antibody deposited at the ECACC on Feb. 26, 1992 under No. 92022605.
A humanized antibody that specifically binds to the human interferon type I receptor.
A human monoclonal antibody that specifically binds to the extracellular domain of the human interferon type I receptor.
Dependencies are inferred from the claim text.