Process for the production of pseudolatices and micro- or nanoparticles and pharmaceutical preparations containing them
AssigneePharmatech GmbH
InventorsBernd W. Muller, Felix Junis-Specht
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Abstract
The invention relates to a process for the production of pseudolatices or micro- and/or nanoparticles, in which a polymer is crystalline, partially crystalline or amorphous, is selected from cellulose derivatives, poly(meth)acrylates, shellac, polylactides, polylactide/polyglycolide mixtures, polyhydroxy butyric acids or polycyanoacrylates and is heated to a temperature above its glass transition temperature and then high-pressure homogenized in water or an aqueous buffer solution and this suspension is converted, if necessary, into micro- and/or nanoparticles by drying. Medicaments can be worked into the pseudolatices, micro- and/or nanoparticles.
Claims12
A process for the production of pseudolatices and micro- and/or nanoparticles, comprising the steps of:
- (a) heating and softening a crystalline, partially crystalline or amorphous polymer selected from the group consisting of cellulose derivatives, poly (meth)acrylates, shellac, polylactides, polylactide/polyglycolide mixtures polyhydroxy butyric acids and polycyanoacrylates to a temperature above its glass transition temperature and below its melting point, and then
- (b) at a pressure of about 100 to about 1,000 bar homogenizing the heated, softened polymer in an aqueous medium which is water or an aqueous buffer solution to form a suspension and, optionally
- (c) drying the suspension and recovering the micro- and/or nanoparticles.
Dependencies are inferred from the claim text.