1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods

A compound of formula 1 ##STR11## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is selected from the group consisting of

• hydrogen,
• hydroxy,
• alkoxy of one to four carbon atoms,
• alkoxycarbonyl of two to seven carbon atoms,
• alkoxycarbonyloxy of two to seven carbon atoms,
• alkylsulfonyloxy,
• phenoxycarbonyloxy, and
• aryloxycarbonyl where the aryl portion is selected from the group consisting of
• unsubstituted phenyl, and
• phenyl substituted with one or more substituents independently selected from the group consisting of
• halo,
• methyl,
• methoxy,
• nitro, and
• trifluoromethyl;
• R.sup.2 and R.sup.3 are, independently selected from the group consisting of
• hydrogen,
• chloro,
• fluoro,
• hydroxy,
• alkoxy of one to four carbon atoms,
• alkoxycarbonyl of two to seven carbon atoms,
• alkoxycarbonyloxy of two to seven carbon atoms,
• alkylsulfonyloxy,
• phenoxycarbonyloxy, and
• aryloxycarbonyl where the aryl portion is selected from the group consisting of
• unsubstituted phenyl, and
• phenyl substituted with one or more substituents independently selected from the group consisting of
• halo,
• methyl,
• methoxy,
• nitro, and
• trifluoromethyl;
• R.sup.4 is selected from the group consisting of
• hydroxy,
• alkoxy of one to six carbon atoms,
• cycloalkoxy of four to six carbon atoms,
• 1-piperidinyl,
• 1-pyrrolidinyl,
• methyl-1-pyrrolidinyl,
• dimethyl-1-pyrrolidino,
• 4-morpholino,
• dimethylamino,
• diethylamino,
• diisopropylamino,
• 1-hexamethyleneimino, and
• aryloxy where wherein the aryl portion is selected from the group consisting of
• unsubstituted phenyl, and
• phenyl substituted with one or more substituents independently selected from the group consisting of
• halo,
• methyl,
• methoxy,
• nitro, and
• trifluoromethyl;
• X is selected from the group consisting of
• alkylene of two to four carbon atoms,
• --CH.dbd.CH--,
• --CH.sub.2 CH.dbd.CH--, and
• --CH.sub.2 CH.sub.2 CH.dbd.CH--;
• and
• Y is absent or is carbonyl, with the proviso that when
• Y is absent, R.sup.4 may not be hydroxy, --O(C.sub.1 -C.sub.6 alkyl), --O(C.sub.4 -C.sub.6 cycloalkyl), or --OAr.